(S)-4-(1-(2-aminopropyl)-1H-pyrazol-3-yl)-2-chloro-6-fluorobenzonitrile → HCID 86714682, compound

Participants

Reaction Steps

The title compound was prepared using the procedure described in Example 32(e) starting from 5-(2-hydroxy-2-methylpropyl)-1-((2-(trimethylsilyl)ethoxy)-methyl)-1H-pyrazole-3-carboxylic acid (1.59 mmol, 500 mg) and (S)-4-(1-(2-amino-propyl)-1H-pyrazol-3-yl)-2-chloro-6-fluorobenzonitrile (1.59 mmol, 442 mg). The product was purified by flash-chromatography. Yield 295 mg. 1H-NMR (400 MHz; DMSO-d6): δ −0.13 (s, 9H), 0.68 (t, 2H), 1.06 (s, 3H), 1.08 (s, 3H), 1.20 (d, 3H), 2.61 (s, 2H), 3.40 (t, 2H), 4.23-4.42 (m, 3H), 4.51 (s, 1H), 5.54 (d, 1H), 5.68 (d, 1H), 6.72 (s, 1H), 7.01 (d, 1H), 7.84-7.87 (m, 2H), 7.96 (s, 1H), 8.40 (d, 1H). LC-MS: [M+1]=575.01.

Provenance & Evidence