Carbon Dioxide → HCID 86689249, compound

Participants

Reaction Steps

7-Bromo-3-chloro-1-fluorospiro[chromeno[2,3-c]pyridine-5,3′-pyrrolo[3,4-c]pyridin]-1′-amine (483 mg) was subjected to chromatography using supercritical CO2 (additives 35% MeOH with 20 mM NH3) on a ChiralPak ADH (21×250 mm, 5 μm) eluting at a flow rate 65 ml/min (100 bar pressure, 40° C. column temperature). The first peak (retention time=1.8 min) provided (R)-7-Bromo-3-chloro-1-fluorospiro[chromeno[2,3-c]pyridine-5,3′-pyrrolo[3,4-c]pyridin]-1′-amine (Example 14c-1, >99% ee), and the second peak (retention time=3.5 min) provided (S)-7-Bromo-3-chloro-1-fluorospiro[chromeno[2,3-c]pyridine-5,3′-pyrrolo[3,4-c]pyridin]-1′-amine (Example 14c-2, >99% ee).

Provenance & Evidence