Carbon Dioxide → HCID 86689256, compound

Participants

Reaction Steps

7-Bromo-3-chloro-1-fluorospiro[chromeno[2,3-c]pyridine-5,5′-pyrrolo[3,4-b]pyridin]-7′-amine subjected to chromatography using supercritical CO2 (additives 50% MeOH with 20 mM NH3) on a Chiralpak ADH column (21×250 mm, 5 μm) eluting at a flow rate 63 ml/min (100 bar pressure, 40° C. column temperature). The first peak (retention time=2.34 min) provided (R)-7-Bromo-3-chloro-1-fluorospiro[chromeno[2,3-c]pyridine-5,5′-pyrrolo[3,4-b]pyridin]-7′-amine (Example 17c-1; 99% ee), and the second peak (retention time=3.98 min) provided (S)-7-Bromo-3-chloro-1-fluorospiro[chromeno[2,3-c]pyridine-5,5′-pyrrolo[3,4-b]pyridin]-7′-amine (Example 17c-2; 99% ee).

Provenance & Evidence