2-Fluoropyridine-3-boronic acid → HCID 56654479, compound

HRID 1409527Notes

Reaction equation

HRID 1409527 reaction equation
Br[C:2]1[CH:3]=[C:4]2[C:15]3([C:20]4[N:21]=[CH:22][CH:23]=[CH:24][C:19]=4[O:18][C:17]([NH2:25])=[N:16]3)[C:14]3[CH:13]=[C:12]([Cl:26])[N:11]=[CH:10][C:9]=3[O:8][C:5]2=[CH:6][CH:7]=1.[F:27][C:28]1[C:33](B(O)O)=[CH:32][CH:31]=[CH:30][N:29]=1>>[Cl:26][C:12]1[N:11]=[CH:10][C:9]2[O:8][C:5]3[C:4]([C:15]4([C:20]5[N:21]=[CH:22][CH:23]=[CH:24][C:19]=5[O:18][C:17]([NH2:25])=[N:16]4)[C:14]=2[CH:13]=1)=[CH:3][C:2]([C:33]1[C:28]([F:27])=[N:29][CH:30]=[CH:31][CH:32]=1)=[CH:7][CH:6]=3

Participants

3

Reactant 2

HCID 27832702-Fluoropyridine-3-boronic acidHCID 86689265HCID 86689265, compound

Product 1

HCID 56654479HCID 56654479, compound

Procedure

The titled compound was prepared by using 7-bromo-3-chlorospiro[chromeno[2,3-c]pyridine-5,4′-pyrido[2,3-e][1,3]oxazin]-2′-amine and 2-fluoropyridine-3-boronic acid and following the procedures as described in Example 18, Step 4. MS m/z=446.0 [M+H]+.

Sources & evidence

ORD record
ord-d6276cf5d22b42b3b107fdfe0e8acf6d
Source dataset
uspto-grants-2014_12
Patent number
US08921363B2

Reaction notes

Loading…