2-Fluoropyridine-3-boronic acid → HCID 56654818, compound

HRID 1409529Notes

Reaction equation

HRID 1409529 reaction equation
Br[C:2]1[CH:3]=[C:4]2[C:15]3([C:20]4[CH:21]=[CH:22][CH:23]=[N:24][C:19]=4[O:18][C:17]([NH2:25])=[N:16]3)[C:14]3[CH:13]=[C:12](Cl)[N:11]=[CH:10][C:9]=3[O:8][C:5]2=[CH:6][CH:7]=1.[F:27][C:28]1[C:33](B(O)O)=[CH:32][CH:31]=[CH:30][N:29]=1.[F:37][C:38]1[CH:43]=[C:42](B(O)O)[CH:41]=[CH:40][N:39]=1>>[F:27][C:28]1[C:33]([C:2]2[CH:3]=[C:4]3[C:15]4([C:20]5[CH:21]=[CH:22][CH:23]=[N:24][C:19]=5[O:18][C:17]([NH2:25])=[N:16]4)[C:14]4[CH:13]=[C:12]([C:42]5[CH:41]=[CH:40][N:39]=[C:38]([F:37])[CH:43]=5)[N:11]=[CH:10][C:9]=4[O:8][C:5]3=[CH:6][CH:7]=2)=[CH:32][CH:31]=[CH:30][N:29]=1

Participants

4

Reactant 3

HCID 27832702-Fluoropyridine-3-boronic acidHCID 27833962-Fluoropyridine-4-boronic acidHCID 86689266HCID 86689266, compound

Product 1

HCID 56654818HCID 56654818, compound

Procedure

The titled compound was prepared by following the procedures as described in Example 18, Step 4 but using 7-bromo-3-chlorospiro[chromeno[2,3-c]pyridine-5,4′-pyrido[3,2-e][1,3]oxazin]-2′-amine, 2-fluoropyridine-3-boronic acid and 2-fluoropyridine-4-boronic acid. MS m/z=506.9 [M+H]+.

Sources & evidence

ORD record
ord-7aa63bc762244b31b880ce74f9b5e313
Source dataset
uspto-grants-2014_12
Patent number
US08921363B2

Reaction notes

Loading…