Ethanol → Ethyl 5-amino-3-(2-hydroxyethoxy)-1H-pyrazole-4-carboxylate

HRID 1409545Notes

Reaction equation

HRID 1409545 reaction equation
[C:1]([C:3]([C:10]([O:12][CH2:13][CH3:14])=[O:11])=[CH:4]C1OCCO1)#[N:2].Cl.[NH2:16][NH2:17].[C:18]([O-:21])(=O)[CH3:19].[Na+].C([OH:25])C>>[NH2:2][C:1]1[C:3]([C:10]([O:12][CH2:13][CH3:14])=[O:11])=[C:4]([O:25][CH2:19][CH2:18][OH:21])[NH:17][N:16]=1

Participants

5

Reactant 4

HCID 702EthanolHCID 115031Hydrazinium chlorideHCID 517045Sodium AcetateHCID 67272950HCID 67272950, compound

Product 1

HCID 135678304Ethyl 5-amino-3-(2-hydroxyethoxy)-1H-pyrazole-4-carboxylateYield 86%

Conditions

Temperature
80 °C

Procedure

To a solution of 2-[(cyano)(ethoxycarbonyl)vinyl]-1,3-dioxolane (2.0 g) in ethanol (20 mL) were added hydrazine hydrochloride (748 mg) and sodium acetate (1.34 g), and the mixture was stirred at 80° C. (external temperature) for 1 hour. After cooling to room temperature, the reaction mixture was filtered through Celite, and the filtrate was concentrated in vacuo. The resultant crude product was purified by column chromatography on silica gel (solvent: chloroform/methanol=100/0 to 85/15) to give 3-amino-4-ethoxycarbonyl-5-[2-(hydroxy)ethoxy]-1H-pyrazole (2.01 g, yield: 86%) as a pale pink solid.

Workup

  1. temperatureAfter cooling to room temperature
  2. filtrationthe reaction mixture was filtered through Celite
  3. concentrationthe filtrate was concentrated in vacuo
  4. customThe resultant crude product was purified by column chromatography on silica gel (solvent: chloroform/methanol=100/0 to 85/15)

Sources & evidence

ORD record
ord-3049afcce7d44031abd2915bc095e346
Source dataset
uspto-grants-2014_12
Patent number
US08921380B2

Reaction notes

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