反应详情

NaBH4 (3.2 g, 86.2 mmol) was added portion wise to a cooled (ice bath) solution of 1-phenyl-cyclopentanecarbaldehyde (7.5 g, 43.1 mmol) in methanol (100 ml) and then stirred for 16 h at RT. After completion of the reaction, it was quenched with saturated ammonium chloride solution and the methanol under reduced pressure. The mixture was diluted with water, extracted with EtOAc, washed with water, brine, dried (Na2SO4) and evaporated to dryness under reduced pressure. Chromatography (15% EtOAc in hexanes) provided (1-phenyl-cyclopentyl)-methanol as a white solid (6 g, 79.8%).

1. customAfter completion of the reaction, it
2. customwas quenched with saturated ammonium chloride solution
3. additionThe mixture was diluted with water
4. extractionextracted with EtOAc
5. washwashed with water, brine
6. dry with materialdried (Na2SO4)
7. customevaporated to dryness under reduced pressure