Ammonia → HCID 136268151, compound

Participants

Reaction Steps

A solution of methyl 5,6-dihydroxy-2-((1-phenylcyclopentyl)methyl)pyrimidine-4-carboxylate (0.020 g, 60.9 μmol) in ammonia in MeOH (435 μl, 3.05 mmol) was heated at 100° C. for 20 min. The cooled solution was evaporated to dryness. The residue was diluted with MeOH and heated in the presence of Amberlyst resin (H+) until in solution. The material was filtered to remove the resin and evaporated to dryness. Trituration with MeOH followed by washing with Et2O provided the desired product as a white solid (0.011 g; 49%). LCMS: m/z=314 (MH+).

Provenance & Evidence