HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-Ethoxycarbonylmethyl-2-methyl-3-(1-phenyl-cyclopentylmethyl)-2,5-dihydro-[1,2,4]oxadiazole-5-carboxylic acid ethyl ester → 5-Hydroxy-1-methyl-6-oxo-2-(1-phenyl-cyclopentylmethyl)-1,6-dihydro-pyrimidine-4-carboxylic acid ethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-Ethoxycarbonylmethyl-2-methyl-3-(1-phenyl-cyclopentylmethyl)-2,5-dihydro-[1,2,4]oxadiazole-5-carboxylic acid ethyl ester | HCID 86710261 | — |
| Reactant | Methyl 5,6-dihydroxy-2-((1-phenylcyclopentyl)methyl)pyrimidine-4-carboxylate | HCID 136377077 | — |
| Product | 5-Hydroxy-1-methyl-6-oxo-2-(1-phenyl-cyclopentylmethyl)-1,6-dihydro-pyrimidine-4-carboxylic acid ethyl ester | HCID 86710260 | — |
Reaction Steps
5-Hydroxy-1-methyl-6-oxo-2-(1-phenyl-cyclopentylmethyl)-1,6-dihydro-pyrimidine-4-carboxylic acid ethyl ester was synthesized as a brown solid (35 mg, 20%) from 200 mg of 5-ethoxycarbonylmethyl-2-methyl-3-(1-phenyl-cyclopentylmethyl)-2,5-dihydro-[1,2,4]oxadiazole-5-carboxylic acid ethyl ester following the procedure described for 5-hydroxy-6-oxo-2-(1-phenyl-cyclopentylmethyl)-1,6-dihydro-pyrimidine-4-carboxylic acid methyl ester (Example 6). LCMS: m/z=357.0 (MH+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08921388B2 |
| Source dataset | uspto-grants-2014_12 |
| ORD ID | ord-a528acfcb7ad41e1a3159ac8a6da45c0 |
| Source note | uspto-grants-2014_12 |