Methylamine → HCID 86710264, compound

Participants

Reaction Conditions

Reaction Steps

A sealed tube containing 2M solution of methylamine (1.71 ml, 3.42 mmol) in THF and methyl 2-(biphenyl-2-ylmethyl)-5-hydroxy-1-methyl-6-oxo-1,6-dihydropyrimidine-4-carboxylate (0.1 g, 285 μmol) was heated at 100° C. in a microwave oven for 20 min, cooled and filtered. The solid was stirred in MeOH, in the presence of Amberlyst 15 IE resin, at 60° C. for 5 min and then at room temperature for 1 h, filtered, evaporated to dryness and triturated with Et2O to give the title compound as a white solid (0.040 g; 40%). LCMS: m/z=351 (MH+).

Provenance & Evidence