Isopropylamine → HCID 136377082, compound

Participants

Reaction Conditions

Reaction Steps

A sealed tube containing propan-2-amine (347 mg, 500 μl, 5.87 mmol), methyl 2-(biphenyl-2-ylmethyl)-5-hydroxy-6-oxo-1,6-dihydropyrimidine-4-carboxylate (0.50 g, 148 μmol) was heated at 150° C. in a microwave oven for 10 minutes. The crude reaction mixture was cooled and evaporated to dryness. The solid residue was stirred in MeOH, in the presence of Amberlyst 15 IE resin, at 60° C. for 5 min and then at room temperature for 1 h, filtered, evaporated to dryness and triturated with Et2O to give the title compound as a white solid (0.012 g; 22%). LCMS: m/z=364 (MH+).

Provenance & Evidence