Benzylamine → HCID 136268155, compound

HRID 1409567Notes

Reaction equation

HRID 1409567 reaction equation
[C:1]1([C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[CH2:7][C:8]1[NH:9][C:10](=[O:19])[C:11]([OH:18])=[C:12]([C:14]([O:16]C)=O)[N:13]=1.[CH2:26]([NH2:33])[C:27]1[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=1>>[CH2:26]([NH:33][C:14]([C:12]1[N:13]=[C:8]([CH2:7][C:2]2[CH:3]=[CH:4][CH:5]=[CH:6][C:1]=2[C:20]2[CH:21]=[CH:22][CH:23]=[CH:24][CH:25]=2)[NH:9][C:10](=[O:19])[C:11]=1[OH:18])=[O:16])[C:27]1[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=1

Participants

3

Reactant 2

HCID 7504BenzylamineHCID 136377081HCID 136377081, compound

Product 1

HCID 136268155HCID 136268155, compoundYield 64.3%

Procedure

The synthesis was performed as in Example 21 using methyl 2-(biphenyl-2-ylmethyl)-5-hydroxy-6-oxo-1,6-dihydropyrimidine-4-carboxylate (0.070 g, 208 μmol) and benzylamine (0.5 ml; 4.58 mmol) to provide the title compound as an off-white solid (0.055 g; 64%). LCMS: m/z=412 (MH+).

Sources & evidence

ORD record
ord-08c3c1316f0249ceafb85891542d0d7b
Source dataset
uspto-grants-2014_12
Patent number
US08921388B2

Reaction notes

Loading…