Isopropylamine → HCID 136377082, compound

HRID 1409570Notes

Reaction equation

[C:1]1([C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[CH2:7][C:8]1[NH:9][C:10](=[O:19])[C:11]([OH:18])=[C:12]([C:14]([O:16]C)=O)[N:13]=1.[CH:26]([NH2:29])([CH3:28])[CH3:27]>>[CH:26]([NH:29][C:14]([C:12]1[N:13]=[C:8]([CH2:7][C:2]2[CH:3]=[CH:4][CH:5]=[CH:6][C:1]=2[C:20]2[CH:21]=[CH:22][CH:23]=[CH:24][CH:25]=2)[NH:9][C:10](=[O:19])[C:11]=1[OH:18])=[O:16])([CH3:28])[CH3:27]

Participants

Reactant 2

HCID 6363Isopropylamine

HCID 136377081HCID 136377081, compound

Product 1

HCID 136377082HCID 136377082, compoundYield 54.5%

Procedure

The synthesis was performed as in Example 21 using methyl 2-(biphenyl-2-ylmethyl)-5-hydroxy-6-oxo-1,6-dihydropyrimidine-4-carboxylate (0.10 g, 298 μmol) and isopropylamine (0.5 ml; 6.10 mmol) to provide the title compound as an off-white solid (0.059 g; 54%). LCMS: m/z=412 (MH+).

Sources & evidence

ORD record: ord-065e6e7e5f1b4f038cc1e64b237b2169
Source dataset: uspto-grants-2014_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08921388B2

Reaction notes

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