Ammonia → HCID 136268158, compound

Participants

Reaction Conditions

Reaction Steps

A mixture containing methyl 5-hydroxy-2-((3′-methylbiphenyl-2-yl)methyl)-6-oxo-1,6-dihydropyrimidine-4-carboxylate (55 mg, 157 μmol) and ammonia (7M in MeOH) (4 ml, 28.0 mmol) in MeOH (2 ml) was heated at 100° C. overnight. The cooled reaction mixture was concentrated in vacuo and then triturated from methanol to give the title product as an off-white solid (0.025 g; 47%). LCMS: m/z=336 (MH+).

Provenance & Evidence