Isopropylamine → HCID 136377093, compound

HRID 1409582Notes

Reaction equation

HRID 1409582 reaction equation
CO[C:3]([C:5]1[N:6]=[C:7]([CH2:13][C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=2[Br:20])[NH:8][C:9](=[O:12])[C:10]=1[OH:11])=[O:4].[CH:21]([NH2:24])([CH3:23])[CH3:22]>>[CH:21]([NH:24][C:3]([C:5]1[N:6]=[C:7]([CH2:13][C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=2[Br:20])[NH:8][C:9](=[O:12])[C:10]=1[OH:11])=[O:4])([CH3:23])[CH3:22]

Participants

3

Reactant 2

HCID 6363IsopropylamineHCID 136377092HCID 136377092, compound

Product 1

HCID 136377093HCID 136377093, compoundYield 24.3%

Procedure

The compound was prepared according to the same procedure as in Example 21 using 2-(2-bromo-benzyl)-5-hydroxy-6-oxo-1,6-dihydro-pyrimidine-4-carboxylic acid methyl ester (0.08 g; 0.236 mmol) and isopropylamine (0.4 ml; 4.7 mmol). This gave the title compound as a white solid (0.021 g; 24%). LCMS: m/z=367 (MH+).

Workup

  1. customThe compound was prepared

Sources & evidence

ORD record
ord-c34713f0d0534ce7b34f267634c6ae6d
Source dataset
uspto-grants-2014_12
Patent number
US08921388B2

Reaction notes

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