4-Chlorobenzylamine → HCID 136268170, compound

HRID 1409583Notes

Reaction equation

HRID 1409583 reaction equation
CO[C:3]([C:5]1[N:6]=[C:7]([CH2:13][C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=2[Br:20])[NH:8][C:9](=[O:12])[C:10]=1[OH:11])=[O:4].[Cl:21][C:22]1[CH:29]=[CH:28][C:25]([CH2:26][NH2:27])=[CH:24][CH:23]=1>>[Cl:21][C:22]1[CH:29]=[CH:28][C:25]([CH2:26][NH:27][C:3]([C:5]2[N:6]=[C:7]([CH2:13][C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=3[Br:20])[NH:8][C:9](=[O:12])[C:10]=2[OH:11])=[O:4])=[CH:24][CH:23]=1

Participants

3

Reactant 2

HCID 660364-ChlorobenzylamineHCID 136377092HCID 136377092, compound

Product 1

HCID 136268170HCID 136268170, compound

Procedure

The compound was prepared according to the same procedure as in Example 21 using 2-(2-bromo-benzyl)-5-hydroxy-6-oxo-1,6-dihydro-pyrimidine-4-carboxylic acid methyl ester (0.08 g; 0.236 mmol) and 4-chlorobenzylamine (0.5 ml; 4.1 mmol). The title compound was prepared as a white solid (0.042 g; 39%). LCMS: m/z=449 (MH+).

Workup

  1. customThe compound was prepared

Sources & evidence

ORD record
ord-1e16558a002b4da98d244ce76332ac8a
Source dataset
uspto-grants-2014_12
Patent number
US08921388B2

Reaction notes

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