Methanol → (+/-)-methyl 4-((tetrahydro-2H-pyran-4-yl)((6-(4-(trifluoromethyl)-1H-pyrazol-1-yl)pyridin-3-yl)amino)methyl)benzoate

HRID 140966Notes

Reaction equation

HRID 140966 reaction equation
[CH3:35][OH:36].[F:19][C:20]([c:21]1[cH:22][n:23][n:24](-[c:26]2[cH:27][cH:28][c:29]([NH2:32])[cH:30][n:31]2)[cH:25]1)([F:33])[F:34].[O:1]1[CH2:2][CH2:3][CH:4]([C:7](=[O:8])[c:9]2[cH:10][cH:11][c:12]([C:13](=[O:14])[O:15][CH3:16])[cH:17][cH:18]2)[CH2:5][CH2:6]1>>[O:1]1[CH2:2][CH2:3][CH:4]([CH:7]([c:9]2[cH:10][cH:11][c:12]([C:13](=[O:14])[O:15][CH3:16])[cH:17][cH:18]2)[NH:32][c:29]2[cH:28][cH:27][c:26](-[n:24]3[n:23][cH:22][c:21]([C:20]([F:19])([F:33])[F:34])[cH:25]3)[n:31][cH:30]2)[CH2:5][CH2:6]1

Participants

4

Reactant 3

HCID 887MethanolHCID 641732966-(4-(trifluoromethyl)-1H-pyrazol-1-yl)pyridin-3-amineHCID 68156933methyl 4-(tetrahydro-2H-pyran-4-carbonyl)benzoate

Product 1

HCID 68156806(+/-)-methyl 4-((tetrahydro-2H-pyran-4-yl)((6-(4-(trifluoromethyl)-1H-pyrazol-1-yl)pyridin-3-yl)amino)methyl)benzoate

Sources & evidence

ORD record
ord-45a00ab2af9f442f9e6405046bfb8c1d
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Reaction notes

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