Phenacyl bromide → HCID 71237789, compound

Participants

Reaction Steps

(3R,4R)-4-[5-(4-chlorophenyl)-1H-pyrazol-3-yl]-3-(4-fluorophenyl)piperidine (100 mg, 0.213 mmol, prepared in a similar manner to Examples 7 and 8), 2-bromoaceto-phenone (50.8 mg, 0.255 mmol) and potassium carbonate (147 mg, 1.064 mmol) in acetonitrile (1.0 ml) was stirred at rt for 4 h. Direct purification of the crude reaction mixture by RP-HPLC (C18, acetonitrile, water, 0.1% TFA) afforded the title compound. HPLC/MS: 474.3, 476.3 (M+1); Rt=1.74 min (LC-4 HPLC conditions).

Provenance & Evidence