(4-Cyano-3-fluorophenyl)boronic acid → HCID 71093761, compound

HRID 1409690Notes

Reaction equation

HRID 1409690 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][CH:11]([N:14]([C:18]([C:20]2[CH:21]=[N:22][C:23](Cl)=[N:24][CH:25]=2)=[O:19])[CH:15]2[CH2:17][CH2:16]2)[CH2:10][CH2:9]1)=O)(C)(C)C.[C:27]([C:29]1[CH:34]=[CH:33][C:32](B(O)O)=[CH:31][C:30]=1[F:38])#[N:28]>>[CH:15]1([N:14]([CH:11]2[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]2)[C:18]([C:20]2[CH:25]=[N:24][C:23]([C:32]3[CH:33]=[CH:34][C:29]([C:27]#[N:28])=[C:30]([F:38])[CH:31]=3)=[N:22][CH:21]=2)=[O:19])[CH2:16][CH2:17]1

Participants

3

Reactant 2

HCID 2783130(4-Cyano-3-fluorophenyl)boronic acidHCID 866861524-[(2-Chloro-pyrimidine-5-carbonyl)-cyclopropyl-amino]-piperidine-1-carboxylic acid tert-butyl ester

Product 1

HCID 71093761HCID 71093761, compound

Procedure

The title compound is prepared from 4-[(2-chloro-pyrimidine-5-carbonyl)-cyclopropyl-amino]-piperidine-1-carboxylic acid tert-butyl ester and 4-cyano-3-fluorophenylboronic acid following a procedure analogous to that described in Intermediate 6. LC (method 4): tR=0.97 min; Mass spectrum (ESI+): m/z=366 [M+H]+.

Sources & evidence

ORD record
ord-53f347853e5d404c86be678d262db606
Source dataset
uspto-grants-2014_12
Patent number
US08921398B2

Reaction notes

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