1,4-Dioxa-8-aza-spiro[4.5]decane-8-carbonitrile → HCID 68289918, compound

HRID 1409708Notes

Reaction equation

HRID 1409708 reaction equation
[O:1]1[C:5]2([CH2:10][CH2:9][N:8]([C:11]#[N:12])[CH2:7][CH2:6]2)[O:4][CH2:3][CH2:2]1.[OH:13][NH:14][C:15](=N)[CH:16]([CH3:18])[CH3:17]>>[CH:16]([C:15]1[N:12]=[C:11]([N:8]2[CH2:7][CH2:6][C:5]3([O:4][CH2:3][CH2:2][O:1]3)[CH2:10][CH2:9]2)[O:13][N:14]=1)([CH3:18])[CH3:17]

Participants

3

Reactant 2

HCID 866782101,4-Dioxa-8-aza-spiro[4.5]decane-8-carbonitrileHCID 178449908HCID 178449908, compound

Product 1

HCID 68289918HCID 68289918, compound

Procedure

The title compound is prepared from 1,4-dioxa-8-aza-spiro[4.5]decane-8-carbonitrile and N-hydroxy-isobutyramidine following a procedure analogous to that described in Intermediate 2. LC (method 17): tR=1.56 min; Mass spectrum (ESI+): m/z=254 [M+H]+.

Sources & evidence

ORD record
ord-5c6f47c2597640c6beab540f3012b6aa
Source dataset
uspto-grants-2014_12
Patent number
US08921398B2

Reaction notes

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