Cyclopropylamine → N-cyclopropyl-1-(5-methylpyrimidin-2-yl)piperidin-4-amine

HRID 1409721Notes

Reaction equation

[CH3:1][C:2]1[CH:3]=[N:4][C:5]([N:8]2[CH2:13][CH2:12][C:11](=O)[CH2:10][CH2:9]2)=[N:6][CH:7]=1.[CH:15]1([NH2:18])[CH2:17][CH2:16]1>>[CH:15]1([NH:18][CH:11]2[CH2:12][CH2:13][N:8]([C:5]3[N:4]=[CH:3][C:2]([CH3:1])=[CH:7][N:6]=3)[CH2:9][CH2:10]2)[CH2:17][CH2:16]1

Participants

Reactant 2

HCID 69828Cyclopropylamine

HCID 632083221-(5-Methylpyrimidin-2-yl)piperidin-4-one

Product 1

HCID 68290030N-cyclopropyl-1-(5-methylpyrimidin-2-yl)piperidin-4-amine

Procedure

The title compound is prepared from 1-(5-methyl-pyrimidin-2-yl)-piperidin-4-one and cyclopropylamine following a procedure analogous to that described in Intermediate 4. LC (method 7): tR=0.55 min; Mass spectrum (ESI+): m/z=233 [M+H]+.

Sources & evidence

ORD record: ord-c3247a2a2951403da9f0acdf08e3385b
Source dataset: uspto-grants-2014_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08921398B2

Reaction notes

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