HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diisopropylethylamine → HCID 63343352, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | 3,4-Difluorobenzonitrile | HCID 587203 | — |
| Reactant | HCID 178524800 | HCID 178524800 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 63343352 | HCID 63343352 | — |
Reaction Conditions
| Temperature | 120 °C |
|---|
Reaction Steps
A mixture of 1H-imidazole-4-carboxylic acid (500 mg), 4-fluoro-3-fluorobenzonitrile (0.93 g), and N,N-diisopropyl-ethyl amine (3.6 mL) in N,N-dimethylformamide (6 mL) is heated to 120° C. overnight. The crude product is purified by HPLC. LC (method 20): tR=1.85 min; Mass spectrum (APCI): m/z=232 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08921398B2 |
| Source dataset | uspto-grants-2014_12 |
| ORD ID | ord-0d5f34615ed947d3a47ddf81295c6f1e |
| Source note | uspto-grants-2014_12 |