HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diisopropylethylamine → 1-(2-Fluoro-4-methanesulfonylphenyl)-1H-imidazole-4-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | 1,2-Difluoro-4-(methylsulfonyl)benzene | HCID 2782743 | — |
| Reactant | HCID 178524800 | HCID 178524800 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 1-(2-Fluoro-4-methanesulfonylphenyl)-1H-imidazole-4-carboxylic acid | HCID 71093750 | — |
Reaction Conditions
| Temperature | 120 °C |
|---|
Reaction Steps
A mixture of 1H-imidazole-4-carboxylic acid (500 mg), 1,2-difluoro-4-methanesulfonylbenzene (1.2 g), and N,N-diisopropyl-ethyl-amine (4 mL) in N,N-dimethylformamide (6 mL) is heated to 120° C. overnight. The crude product is purified by HPLC. LC (method 20): tR=1.69 min; Mass spectrum (APCI): m/z=285 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08921398B2 |
| Source dataset | uspto-grants-2014_12 |
| ORD ID | ord-3ed85d0efecc41b0a3b6ab6f27e9acf9 |
| Source note | uspto-grants-2014_12 |