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Diisopropylethylamine → 1-(2-Fluoro-4-methanesulfonylphenyl)-2-methyl-1H-imidazole-4-carboxylic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Diisopropylethylamine | HCID 81531 | — |
| 反応物 | 1,2-Difluoro-4-(methylsulfonyl)benzene | HCID 2782743 | — |
| 反応物 | HCID 178433052 | HCID 178433052 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | 1-(2-Fluoro-4-methanesulfonylphenyl)-2-methyl-1H-imidazole-4-carboxylic acid | HCID 71093776 | — |
反応手順
A mixture of 2-methyl-1H-imidazole-4-carboxylic acid (500 mg), N,N-diisopropyl-ethyl-amine (4 mL), and 1,2-difluoro-4-methanesulfonylbenzene (1.2 g), in N,N-dimethylformamide (6 mL) is heated to 120° C. overnight. The crude product is purified by HPLC. LC (method 20): tR=0.90 min; Mass spectrum (APCI): m/z=299 [M+H]+.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08921398B2 |
| 出典データセット | uspto-grants-2014_12 |
| ORD ID | ord-67f3a97b89934ddf9a668c8742595daa |
| 出典メモ | uspto-grants-2014_12 |