2-Chloro-5-ethylpyrimidine → HCID 68290588, compound

HRID 1409746Notes

Reaction equation

HRID 1409746 reaction equation
[CH:1]1([N:4]([C@H:12]2[CH2:17][CH2:16][NH:15][CH2:14][C@H:13]2[F:18])C(=O)OC(C)(C)C)[CH2:3][CH2:2]1.Cl[C:20]1[N:25]=[CH:24][C:23]([CH2:26][CH3:27])=[CH:22][N:21]=1>>[CH:1]1([NH:4][CH:12]2[CH2:17][CH2:16][N:15]([C:20]3[N:25]=[CH:24][C:23]([CH2:26][CH3:27])=[CH:22][N:21]=3)[CH2:14][CH:13]2[F:18])[CH2:2][CH2:3]1

Participants

3

Reactant 2

HCID 35727632-Chloro-5-ethylpyrimidineHCID 68289942tert-butyl N-cyclopropyl-N-[(3R,4S)-3-fluoropiperidin-4-yl]carbamate

Product 1

HCID 68290588HCID 68290588, compound

Procedure

The title compound is prepared from tert-butyl N-cyclopropyl-N-[(3R,4S)-3-fluoropiperidin-4-yl]carbamate and 2-chloro-5-ethylpyrimidine following a procedure analogous to that described for Intermediate 87. LC (method 20): tR=1.80 min; Mass spectrum (APCI): m/z=265 [M+H]+.

Sources & evidence

ORD record
ord-59482e60d6584cd681bdb744bb8c5365
Source dataset
uspto-grants-2014_12
Patent number
US08921398B2

Reaction notes

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