Diisopropylethylamine → HCID 86686159, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 2-(6-ethoxy-pyridin-3-yl)-pyrimidine-5-carboxylic acid cyclopropyl-piperidin-4-yl-amide trifluoroacetic acid salt (48 mg), ethyldiisopropylamine (52 μL), and 2-chloro-5-ethylpyrimidine (14 mg) in N,N-dimethylformamide (2.0 mL) is stirred at 120° C. for 4 h. After cooling to room temperature, the reaction mixture is purified by HPLC (H2O/MeOH/TFA) to give the title compound. LC (method 3): tR=2.10 min; Mass spectrum (ESI+): m/z=474 [M+H]+.

Provenance & Evidence