2-Chloro-5-ethylpyrimidine → 2-(4-Cyanomethyl-phenyl)-pyrimidine-5-carboxylic acid cyclopropyl-[1-(5-ethyl-pyrimidin-2-yl)-piperidin-4-yl]-amide

HRID 1409753Notes

Reaction equation

HRID 1409753 reaction equation
[CH:1]1([N:4]([CH:22]2[CH2:27][CH2:26][NH:25][CH2:24][CH2:23]2)[C:5]([C:7]2[CH:8]=[N:9][C:10]([C:13]3[CH:18]=[CH:17][C:16]([CH2:19][C:20]#[N:21])=[CH:15][CH:14]=3)=[N:11][CH:12]=2)=[O:6])[CH2:3][CH2:2]1.Cl[C:29]1[N:34]=[CH:33][C:32]([CH2:35][CH3:36])=[CH:31][N:30]=1>>[CH:1]1([N:4]([CH:22]2[CH2:23][CH2:24][N:25]([C:29]3[N:34]=[CH:33][C:32]([CH2:35][CH3:36])=[CH:31][N:30]=3)[CH2:26][CH2:27]2)[C:5]([C:7]2[CH:8]=[N:9][C:10]([C:13]3[CH:14]=[CH:15][C:16]([CH2:19][C:20]#[N:21])=[CH:17][CH:18]=3)=[N:11][CH:12]=2)=[O:6])[CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 35727632-Chloro-5-ethylpyrimidineHCID 710937352-(4-Cyanomethyl-phenyl)-pyrimidine-5-carboxylic acid cyclopropyl-piperidin-4-yl amide

Product 1

HCID 866861602-(4-Cyanomethyl-phenyl)-pyrimidine-5-carboxylic acid cyclopropyl-[1-(5-ethyl-pyrimidin-2-yl)-piperidin-4-yl]-amide

Procedure

The title compound is prepared from 2-(4-cyanomethyl-phenyl)-pyrimidine-5-carboxylic acid cyclopropyl-piperidin-4-yl amide and 2-chloro-5-ethylpyrimidine following a procedure analogous to that described in Example 3. LC (method 3): tR=1.84 min; Mass spectrum (ESI+): m/z=468 [M+H]+.

Sources & evidence

ORD record
ord-727d25bfa81844e1b4e6dc60b9f91fb4
Source dataset
uspto-grants-2014_12
Patent number
US08921398B2

Reaction notes

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