2-(6-Ethoxy-pyridin-3-yl)-pyrimidine-5-carboxylic acid (1-cyano-piperidin-4-yl)-cyclopropyl-amide → HCID 71112659, compound

HRID 1409758Notes

Reaction equation

HRID 1409758 reaction equation
[C:1]([N:3]1[CH2:8][CH2:7][CH:6]([N:9]([CH:27]2[CH2:29][CH2:28]2)[C:10]([C:12]2[CH:13]=[N:14][C:15]([C:18]3[CH:19]=[N:20][C:21]([O:24][CH2:25][CH3:26])=[CH:22][CH:23]=3)=[N:16][CH:17]=2)=[O:11])[CH2:5][CH2:4]1)#[N:2].[OH:30][NH:31][C:32](=N)[CH2:33][CH3:34]>>[CH:27]1([N:9]([CH:6]2[CH2:5][CH2:4][N:3]([C:1]3[O:30][N:31]=[C:32]([CH2:33][CH3:34])[N:2]=3)[CH2:8][CH2:7]2)[C:10]([C:12]2[CH:13]=[N:14][C:15]([C:18]3[CH:19]=[N:20][C:21]([O:24][CH2:25][CH3:26])=[CH:22][CH:23]=3)=[N:16][CH:17]=2)=[O:11])[CH2:28][CH2:29]1

Participants

3

Reactant 2

HCID 866861622-(6-Ethoxy-pyridin-3-yl)-pyrimidine-5-carboxylic acid (1-cyano-piperidin-4-yl)-cyclopropyl-amideHCID 178458070HCID 178458070, compound

Product 1

HCID 71112659HCID 71112659, compound

Procedure

The title compound is prepared from 2-(6-ethoxy-pyridin-3-yl)-pyrimidine-5-carboxylic acid (1-cyano-piperidin-4-yl)-cyclopropyl-amide and N-hydroxy-propionamidine following a procedure analogous to that described in Example 6. LC (method 3): tR=1.96 min; Mass spectrum (ESI+): m/z=464 [M+H]+.

Sources & evidence

ORD record
ord-32008c826d86450ea969af2792ea377b
Source dataset
uspto-grants-2014_12
Patent number
US08921398B2

Reaction notes

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