2-Chloro-5-ethylpyrimidine → 2-(2-Ethyl-imidazol-1-yl)-pyrimidine-5-carboxylic acid cyclopropyl-[1-(5-ethyl-pyrimidin-2-yl)-piperidin-4-yl]-amide

HRID 1409763Notes

Reaction equation

HRID 1409763 reaction equation
[CH:1]1([N:4]([CH:20]2[CH2:25][CH2:24][NH:23][CH2:22][CH2:21]2)[C:5]([C:7]2[CH:8]=[N:9][C:10]([N:13]3[CH:17]=[CH:16][N:15]=[C:14]3[CH2:18][CH3:19])=[N:11][CH:12]=2)=[O:6])[CH2:3][CH2:2]1.Cl[C:27]1[N:32]=[CH:31][C:30]([CH2:33][CH3:34])=[CH:29][N:28]=1>>[CH:1]1([N:4]([CH:20]2[CH2:21][CH2:22][N:23]([C:27]3[N:32]=[CH:31][C:30]([CH2:33][CH3:34])=[CH:29][N:28]=3)[CH2:24][CH2:25]2)[C:5]([C:7]2[CH:12]=[N:11][C:10]([N:13]3[CH:17]=[CH:16][N:15]=[C:14]3[CH2:18][CH3:19])=[N:9][CH:8]=2)=[O:6])[CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 35727632-Chloro-5-ethylpyrimidineHCID 710937462-(2-Ethyl-imidazol-1-yl)-pyrimidine-5-carboxylic acid cyclopropyl-piperidin-4-yl-amide

Product 1

HCID 866861702-(2-Ethyl-imidazol-1-yl)-pyrimidine-5-carboxylic acid cyclopropyl-[1-(5-ethyl-pyrimidin-2-yl)-piperidin-4-yl]-amide

Procedure

The title compound is prepared from 2-(2-ethyl-imidazol-1-yl)-pyrimidine-5-carboxylic acid cyclopropyl-piperidin-4-yl-amide and 2-chloro-5-ethylpyrimidine following a procedure analogous to that described in Example 3. LC (method 10): tR=1.46 min; Mass spectrum (ESI+): m/z=447 [M+H]+.

Sources & evidence

ORD record
ord-9f5a6e569a5e4939aab3262225141ae2
Source dataset
uspto-grants-2014_12
Patent number
US08921398B2

Reaction notes

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