HCID 86686171, compound → HCID 71112314, compound

HRID 1409764Notes

Reaction equation

HRID 1409764 reaction equation
[C:1]([N:3]1[CH2:8][CH2:7][CH:6]([N:9]([CH:28]2[CH2:30][CH2:29]2)[C:10]([C:12]2[CH:13]=[N:14][C:15]([C:18]3[CH:23]=[CH:22][C:21]([S:24]([CH3:27])(=[O:26])=[O:25])=[CH:20][CH:19]=3)=[N:16][CH:17]=2)=[O:11])[CH2:5][CH2:4]1)#[N:2].[OH:31][NH:32][C:33](=N)[CH2:34][CH2:35][CH3:36]>>[CH:28]1([N:9]([CH:6]2[CH2:5][CH2:4][N:3]([C:1]3[O:31][N:32]=[C:33]([CH2:34][CH2:35][CH3:36])[N:2]=3)[CH2:8][CH2:7]2)[C:10]([C:12]2[CH:13]=[N:14][C:15]([C:18]3[CH:23]=[CH:22][C:21]([S:24]([CH3:27])(=[O:25])=[O:26])=[CH:20][CH:19]=3)=[N:16][CH:17]=2)=[O:11])[CH2:29][CH2:30]1

Participants

3

Reactant 2

HCID 86686171HCID 86686171, compoundHCID 178449909HCID 178449909, compound

Product 1

HCID 71112314HCID 71112314, compound

Procedure

The title compound is prepared from 2-(4-methanesulfonyl-phenyl)-pyrimidine-5-carboxylic acid (1-cyano-piperidin-4-yl)-cyclopropyl-amide and N-hydroxy-butyramidine following a procedure analogous to that described in Example 6. LC (method 10): tR=1.87 min; Mass spectrum (ESI+): m/z=511 [M+H]+.

Sources & evidence

ORD record
ord-c88f28d3d6c84150a4a2ed38dbc09911
Source dataset
uspto-grants-2014_12
Patent number
US08921398B2

Reaction notes

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