HuagongsheHuagongshe Chemistry Print Report · For research reference only
N-cyclopropyl-1-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-4-amine → 5-(4-Cyano-2-fluoro-phenyl)-isoxazole-3-carboxylic acid cyclopropyl-[1-(3-isopropyl-[1,2,4]oxadiazol-5-yl)-piperidin-4-yl]-amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N-cyclopropyl-1-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-4-amine | HCID 68290028 | — |
| Reactant | 5-(4-Cyano-2-fluorophenyl)-1,2-oxazole-3-carboxylic acid | HCID 71093737 | — |
| Product | 5-(4-Cyano-2-fluoro-phenyl)-isoxazole-3-carboxylic acid cyclopropyl-[1-(3-isopropyl-[1,2,4]oxadiazol-5-yl)-piperidin-4-yl]-amide | HCID 86686179 | — |
Reaction Steps
The title compound is prepared from 5-(4-cyano-2-fluoro-phenyl)-isoxazole-3-carboxylic acid and cyclopropyl-[1-(3-isopropyl-[1,2,4]oxadiazol-5-yl)-piperidin-4-yl]-amine following a procedure analogous to that described in Example 18. LC (method 18): tR=1.23 min; Mass spectrum (ESI+): m/z=465 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08921398B2 |
| Source dataset | uspto-grants-2014_12 |
| ORD ID | ord-01578c0daa80426ca05c6bdf135cd498 |
| Source note | uspto-grants-2014_12 |