HuagongsheHuagongshe Chemistry Print Report · For research reference only
Chloro-N,N,N',N'-tetramethylformamidinium Hexafluorophosphate → 5-Oxazol-5-yl-pyrazine-2-carboxylic acid cyclopropyl-[1-(3-isopropyl-[1,2,4]oxadiazol-5-yl)-piperidin-4-yl]amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Chloro-N,N,N',N'-tetramethylformamidinium Hexafluorophosphate | HCID 10989639 | — |
| Reactant | N-cyclopropyl-1-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-4-amine | HCID 68290028 | — |
| Reactant | 5-Oxazol-5-yl-pyrazine-2-carboxylic acid | HCID 86686158 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 5-Oxazol-5-yl-pyrazine-2-carboxylic acid cyclopropyl-[1-(3-isopropyl-[1,2,4]oxadiazol-5-yl)-piperidin-4-yl]amide | HCID 86686181 | — |
Reaction Steps
The title compound is prepared from cyclopropyl-[1-(3-isopropyl-[1,2,4]oxadiazol-5-yl)-piperidin-4-yl]-amine and 5-oxazol-5-yl-pyrazine-2-carboxylic acid following a procedure analogous to that described in Example 1 using chloro-N,N,N′,N′-tetramethylformamidinium hexafluorophosphate as reagent and tetrahydrofuran as solvent. LC (method 8): tR=1.47 min; Mass spectrum (ESI+): m/z=424 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08921398B2 |
| Source dataset | uspto-grants-2014_12 |
| ORD ID | ord-8f529d8125024ed99796c4d8ba03de07 |
| Source note | uspto-grants-2014_12 |