HCID 66759906, compound → N-Cyclopropyl-N-[1-(5-ethyl-pyrimidin-2-yl)-piperidin-4-yl]-6-oxazol-5-yl-nicotinamide

HRID 1409777Notes

Reaction equation

HRID 1409777 reaction equation
[CH:1]1([NH:4][CH:5]2[CH2:10][CH2:9][N:8]([C:11]3[N:16]=[CH:15][C:14]([CH2:17][CH3:18])=[CH:13][N:12]=3)[CH2:7][CH2:6]2)[CH2:3][CH2:2]1.[O:19]1[C:23]([C:24]2[CH:32]=[CH:31][C:27]([C:28](O)=[O:29])=[CH:26][N:25]=2)=[CH:22][N:21]=[CH:20]1>>[CH:1]1([N:4]([CH:5]2[CH2:10][CH2:9][N:8]([C:11]3[N:12]=[CH:13][C:14]([CH2:17][CH3:18])=[CH:15][N:16]=3)[CH2:7][CH2:6]2)[C:28](=[O:29])[C:27]2[CH:31]=[CH:32][C:24]([C:23]3[O:19][CH:20]=[N:21][CH:22]=3)=[N:25][CH:26]=2)[CH2:2][CH2:3]1

Participants

3

Reactant 2

HCID 66759906HCID 66759906, compoundHCID 68289588N-cyclopropyl-1-(5-ethylpyrimidin-2-yl)piperidin-4-amine

Product 1

HCID 71093759N-Cyclopropyl-N-[1-(5-ethyl-pyrimidin-2-yl)-piperidin-4-yl]-6-oxazol-5-yl-nicotinamide

Procedure

The title compound is prepared from cyclopropyl-[1-(5-ethyl-pyrimidin-2-yl)-piperidin-4-yl]-amine and 6-oxazol-5-yl-nicotinic acid following a procedure analogous to that described in Example 1. LC (method 7): tR=1.02 min; Mass spectrum (ESI+): m/z=419 [M+H]+.

Sources & evidence

ORD record
ord-e6087c230c6f4e5fb03e9693519a5ef5
Source dataset
uspto-grants-2014_12
Patent number
US08921398B2

Reaction notes

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