HCID 66759906, compound → N-Cyclopropyl-6-oxazol-5-yl-N-[1-(3-propyl-[1,2,4]oxadiazol-5-yl)-piperidin-4-yl]-nicotinamide

HRID 1409782Notes

Reaction equation

HRID 1409782 reaction equation
[CH:1]1([NH:4][CH:5]2[CH2:10][CH2:9][N:8]([C:11]3[O:15][N:14]=[C:13]([CH2:16][CH2:17][CH3:18])[N:12]=3)[CH2:7][CH2:6]2)[CH2:3][CH2:2]1.[O:19]1[C:23]([C:24]2[CH:32]=[CH:31][C:27]([C:28](O)=[O:29])=[CH:26][N:25]=2)=[CH:22][N:21]=[CH:20]1>>[CH:1]1([N:4]([CH:5]2[CH2:10][CH2:9][N:8]([C:11]3[O:15][N:14]=[C:13]([CH2:16][CH2:17][CH3:18])[N:12]=3)[CH2:7][CH2:6]2)[C:28](=[O:29])[C:27]2[CH:31]=[CH:32][C:24]([C:23]3[O:19][CH:20]=[N:21][CH:22]=3)=[N:25][CH:26]=2)[CH2:2][CH2:3]1

Participants

3

Reactant 2

HCID 66759906HCID 66759906, compoundHCID 68289599HCID 68289599, compound

Product 1

HCID 71112590N-Cyclopropyl-6-oxazol-5-yl-N-[1-(3-propyl-[1,2,4]oxadiazol-5-yl)-piperidin-4-yl]-nicotinamide

Procedure

The title compound is prepared from cyclopropyl-[1-(3-propyl-[1,2,4]oxadiazol-5-yl)-piperidin-4-yl]-amine and 6-oxazol-5-yl-nicotinic acid following a procedure analogous to that described in Example 1. LC (method 7): tR=1.09 min; Mass spectrum (ESI+): m/z=423 [M+H]+.

Sources & evidence

ORD record
ord-b8379f616317422f8630179cab6961a0
Source dataset
uspto-grants-2014_12
Patent number
US08921398B2

Reaction notes

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