Propargylamine → HCID 25211811, compound

Participants

Reaction Steps

Prepared from 5-(5-Trifluoromethyl-4-methyl-isoxazol-3-yl)-thiophene-2-carboxylic acid and propargylamine by the method described in Example 2 Method B. Pale yellow solid (122 mg, 97%). 1H NMR (DMSO-d6) 2.41 (d, J=1.3, 3H), 3.25 (t, J=2.6, 1H), 4.13 (dd, J=5.7, 2.6, 2H), 7.79 (d, J=4.0, 1H), 7.97 (d, J=4.0, 1H), 9.29 (t, J=5.7, 1H). 19F NMR −62.30. LC/MS 6.07 min, [M+1]+ 315.

Provenance & Evidence