2-(1,4-Dioxan-2-yl)acetic acid → HCID 178520372, compound

HRID 1409869Notes

Reaction equation

HRID 1409869 reaction equation
Cl.Cl.[O:3]1[C:8]2=[CH:9][CH:10]=[CH:11][C:7]2=[CH:6][C:5]([CH:12]2[CH2:17][CH2:16][CH2:15][CH2:14][N:13]2[CH2:18][CH2:19][C@H:20]2[CH2:25][CH2:24][C@H:23]([NH2:26])[CH2:22][CH2:21]2)=[CH:4]1.[O:27]1[CH2:32][CH2:31][O:30][CH2:29][CH:28]1[CH2:33][C:34](O)=[O:35]>>[O:3]1[C:8]2=[CH:9][CH:10]=[CH:11][C:7]2=[CH:6][C:5]([CH:12]2[CH2:17][CH2:16][CH2:15][CH2:14][N:13]2[CH2:18][CH2:19][C@H:20]2[CH2:21][CH2:22][C@H:23]([NH:26][C:34](=[O:35])[CH2:33][CH:28]3[CH2:29][O:30][CH2:31][CH2:32][O:27]3)[CH2:24][CH2:25]2)=[CH:4]1

Participants

3

Reactant 2

HCID 184692262-(1,4-Dioxan-2-yl)acetic acidHCID 178478713HCID 178478713, compound2×

Product 1

HCID 178520372HCID 178520372, compound

Procedure

The title compound, white solid (60 mg, 53%), MS (ISP) m/z=455.3 [(M+H)+], mp 172° C., was prepared in accordance with the general method of example 1 from trans-4-[2-(4-benzofuran-3-yl-piperidin-1-yl)-ethyl]-cyclohexylamine dihydrochloride (intermediate A) (100 mg, 0.25 mmol) and (RS)-2-[1,4]dioxan-2-yl-acetic acid.

Sources & evidence

ORD record
ord-d1c466a7d1ad44a9bb02662638fdec41
Source dataset
uspto-grants-2014_12
Patent number
US08921397B2

Reaction notes

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