Cyclopropaneacetic acid → HCID 178520146, compound

HRID 1409886Notes

Reaction equation

Cl.Cl.[O:3]1[C:8]2=[CH:9][CH:10]=[CH:11][C:7]2=[CH:6][C:5]([CH:12]2[CH2:17][CH2:16][CH2:15][CH2:14][N:13]2[CH2:18][CH2:19][C@H:20]2[CH2:25][CH2:24][C@H:23]([NH2:26])[CH2:22][CH2:21]2)=[CH:4]1.[CH:27]1([CH2:30][C:31](O)=[O:32])[CH2:29][CH2:28]1>>[O:3]1[C:8]2=[CH:9][CH:10]=[CH:11][C:7]2=[CH:6][C:5]([CH:12]2[CH2:17][CH2:16][CH2:15][CH2:14][N:13]2[CH2:18][CH2:19][C@H:20]2[CH2:21][CH2:22][C@H:23]([NH:26][C:31](=[O:32])[CH2:30][CH:27]3[CH2:29][CH2:28]3)[CH2:24][CH2:25]2)=[CH:4]1

Participants

Reactant 2

HCID 138440Cyclopropaneacetic acid

HCID 178478713HCID 178478713, compound2×

Product 1

HCID 178520146HCID 178520146, compound

Procedure

The title compound, light yellow solid (74 mg, 73%), MS (ISP) m/z=409.4 [(M+H)+], mp 165° C., was prepared in accordance with the general method of example 1 from trans-4-[2-(4-benzofuran-3-yl-piperidin-1-yl)-ethyl]-cyclohexylamine dihydrochloride (intermediate A) (100 mg, 0.25 mmol) and 2-cyclopropyl-acetic acid.

Sources & evidence

ORD record: ord-1811c3ae1c30485792c77fa6cfa64a6a
Source dataset: uspto-grants-2014_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08921397B2

Reaction notes

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