Oxane-3-carboxylic acid → HCID 178523655, compound

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Reaction Steps

The title compound, light yellow solid (78 mg, 71%), MS (ISP) m/z=439.3 [(M+H)+], mp 188° C., was prepared in accordance with the general method of example 1 from trans-4-[2-(4-benzofuran-3-yl-piperidin-1-yl)-ethyl]-cyclohexylamine dihydrochloride (intermediate A) (100 mg, 0.25 mmol) and (RS)-tetrahydro-pyran-3-carboxylic acid.

Provenance & Evidence