4-(1,1-Dioxidothiomorpholino)benzoic acid → HCID 178523653, compound

HRID 1409925Notes

Reaction equation

HRID 1409925 reaction equation
Cl.Cl.[O:3]1[C:8]2=[CH:9][CH:10]=[CH:11][C:7]2=[CH:6][C:5]([CH:12]2[CH2:17][CH2:16][CH2:15][CH2:14][N:13]2[CH2:18][CH2:19][C@H:20]2[CH2:25][CH2:24][C@H:23]([NH2:26])[CH2:22][CH2:21]2)=[CH:4]1.[O:27]=[S:28]1(=[O:43])[CH2:33][CH2:32][N:31]([C:34]2[CH:42]=[CH:41][C:37]([C:38](O)=[O:39])=[CH:36][CH:35]=2)[CH2:30][CH2:29]1>>[O:3]1[C:8]2=[CH:9][CH:10]=[CH:11][C:7]2=[CH:6][C:5]([CH:12]2[CH2:17][CH2:16][CH2:15][CH2:14][N:13]2[CH2:18][CH2:19][C@H:20]2[CH2:21][CH2:22][C@H:23]([NH:26][C:38](=[O:39])[C:37]3[CH:41]=[CH:42][C:34]([N:31]4[CH2:30][CH2:29][S:28](=[O:43])(=[O:27])[CH2:33][CH2:32]4)=[CH:35][CH:36]=3)[CH2:24][CH2:25]2)=[CH:4]1

Participants

3

Reactant 2

HCID 27638174-(1,1-Dioxidothiomorpholino)benzoic acidHCID 178478713HCID 178478713, compound2×

Product 1

HCID 178523653HCID 178523653, compound

Procedure

The title compound, light yellow solid (116 mg, 82%), MS (ISP) m/z=564.4 [(M+H)+], mp 269° C., was prepared in accordance with the general method of example 1 from trans-4-[2-(4-benzofuran-3-yl-piperidin-1-yl)-ethyl]-cyclohexylamine dihydrochloride (intermediate A) (100 mg, 0.25 mmol) and 4-(1,1-dioxo-1λ6-thiomor-pholin-4-yl)-benzoic acid.

Sources & evidence

ORD record
ord-0421db91657046febed9c047856a0d06
Source dataset
uspto-grants-2014_12
Patent number
US08921397B2

Reaction notes

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