4-(1H-Pyrrol-1-yl)benzoic acid → HCID 178523648, compound

HRID 1409927Notes

Reaction equation

HRID 1409927 reaction equation
Cl.Cl.[O:3]1[C:8]2=[CH:9][CH:10]=[CH:11][C:7]2=[CH:6][C:5]([CH:12]2[CH2:17][CH2:16][CH2:15][CH2:14][N:13]2[CH2:18][CH2:19][C@H:20]2[CH2:25][CH2:24][C@H:23]([NH2:26])[CH2:22][CH2:21]2)=[CH:4]1.[N:27]1([C:32]2[CH:40]=[CH:39][C:35]([C:36](O)=[O:37])=[CH:34][CH:33]=2)[CH:31]=[CH:30][CH:29]=[CH:28]1>>[O:3]1[C:8]2=[CH:9][CH:10]=[CH:11][C:7]2=[CH:6][C:5]([CH:12]2[CH2:17][CH2:16][CH2:15][CH2:14][N:13]2[CH2:18][CH2:19][C@H:20]2[CH2:21][CH2:22][C@H:23]([NH:26][C:36](=[O:37])[C:35]3[CH:39]=[CH:40][C:32]([N:27]4[CH:31]=[CH:30][CH:29]=[CH:28]4)=[CH:33][CH:34]=3)[CH2:24][CH2:25]2)=[CH:4]1

Participants

3

Reactant 2

HCID 27372564-(1H-Pyrrol-1-yl)benzoic acidHCID 178478713HCID 178478713, compound2×

Product 1

HCID 178523648HCID 178523648, compound

Procedure

The title compound, off-white solid (77 mg, 62%), MS (ISP) m/z=496.4 [(M+H)+], mp 212° C., was prepared in accordance with the general method of example 1 from trans-4-[2-(4-benzofuran-3-yl-piperidin-1-yl)-ethyl]-cyclohexylamine dihydrochloride (intermediate A) (100 mg, 0.25 mmol) and 4-pyrrol-1-yl-benzoic acid.

Sources & evidence

ORD record
ord-6694e8057b814efab75f4b710cf617a7
Source dataset
uspto-grants-2014_12
Patent number
US08921397B2

Reaction notes

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