4-t-Butylbenzenesulfonyl chloride → HCID 178441111, compound

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Reaction Steps

The title compound, white solid (92 mg, 70%), MS (ISP) m/z=523.6 [(M+H)+], mp 171° C., was prepared in accordance with the general method of example 36 from trans-4-[2-(4-benzofuran-3-yl-piperidin-1-yl)-ethyl]-cyclohexylamine dihydrochloride (intermediate A) (100 mg, 0.25 mmol) and 4-tert-butyl-benzenesulfonyl chloride.

Provenance & Evidence