2-Bromo-1-(2,4-dimethoxyphenyl)ethanone → Ethyl 1-(2-(2,4-dimethoxyphenyl)-2-oxoethyl)-3-(trimethylsilyl)-1H-pyrazole-5-carboxylate

HRID 1409978Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1409978
COC1C=CC(OC)=CC=1C(=O)CN1C(C(OCC)=O)=CC(C2C=NC=CC=2)=N1.[CH3:30][Si:31]([CH3:43])([CH3:42])[C:32]1[CH:36]=[C:35]([C:37]([O:39][CH2:40][CH3:41])=[O:38])[NH:34][N:33]=1.Br[CH2:45][C:46]([C:48]1[CH:53]=[CH:52][C:51]([O:54][CH3:55])=[CH:50][C:49]=1[O:56][CH3:57])=[O:47]>>[CH3:57][O:56][C:49]1[CH:50]=[C:51]([O:54][CH3:55])[CH:52]=[CH:53][C:48]=1[C:46](=[O:47])[CH2:45][N:34]1[C:35]([C:37]([O:39][CH2:40][CH3:41])=[O:38])=[CH:36][C:32]([Si:31]([CH3:42])([CH3:43])[CH3:30])=[N:33]1

Komponenten

4

Edukt 3

HCID 986832-Bromo-1-(2,4-dimethoxyphenyl)ethanoneHCID 86267540Ethyl 1-(2-(2,5-dimethoxyphenyl)-2-oxoethyl)-3-(pyridin-3-yl)-1H-pyrazole-5-carboxylateHCID 178469409Ethyl 3-(trimethylsilyl)-1H-pyrazole-5-carboxylate

Produkt 1

HCID 86267541Ethyl 1-(2-(2,4-dimethoxyphenyl)-2-oxoethyl)-3-(trimethylsilyl)-1H-pyrazole-5-carboxylate

Versuchsvorschrift

This compound was prepared in a similar method to ethyl 1-(2-(2,5-dimethoxyphenyl)-2-oxoethyl)-3-(pyridin-3-yl)-1H-pyrazole-5-carboxylate using ethyl 3-(trimethyl silyl)-1H-pyrazole-5-carboxylate and 2-bromo-1-(2,4-dimethoxyphenyl)ethanone (purchased from Aldrich). 1H-NMR δ 9.92 (d, 1H), 7.02 (s, 1H), 6.57 (dd, 1H), 6.51 (d, 1H), 5.67 (s, 2H), 4.39 (quartet, 2H), 3.98 (s, 3H), 3.89 (s, 3H), 1.38 (t, 3H), 0.27 (s, 9H).

Quellen und Nachweise

ORD-Eintrag
ord-0e0c7c3e03564388afb388645acdebb0
Quelldatensatz
uspto-grants-2014_12
Patentnummer
US08921401B2

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