Isothiazolo[5,4-b]pyridin-3-ol → HCID 69228848, compound

HRID 1409989Notes

Reaction equation

HRID 1409989 reaction equation
[S:1]1[C:5]2=[N:6][CH:7]=[CH:8][CH:9]=[C:4]2[C:3](=[O:10])[NH:2]1.[CH3:11][CH:12]1[CH2:17][CH2:16][N:15]([C:18](Cl)=[O:19])[CH2:14][CH2:13]1>>[CH3:11][CH:12]1[CH2:17][CH2:16][N:15]([C:18]([O:10][C:3]2[C:4]3[C:5](=[N:6][CH:7]=[CH:8][CH:9]=3)[S:1][N:2]=2)=[O:19])[CH2:14][CH2:13]1

Participants

3

Reactant 2

HCID 2727563Isothiazolo[5,4-b]pyridin-3-olHCID 152215164-Methylpiperidine-1-carbonyl Chloride

Product 1

HCID 69228848HCID 69228848, compound

Procedure

In analogy to example 1, 60 mg (0.4 mmol) of isothiazolo[5,4-b]pyridin-3-one were reacted with 76 mg (0.47 mmol) of 4-methylpiperidine-1-carbonyl chloride. Yield: 29 mg (27%), M+H+: 278.13.

Sources & evidence

ORD record
ord-0f348c81326c4ae590d9b7386bd604f7
Source dataset
uspto-grants-2014_12
Patent number
US08921404B2

Reaction notes

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