1,2-Benzisothiazol-3(2H)-one → HCID 12001419, compound

HRID 1409990Notes

Reaction equation

HRID 1409990 reaction equation
[S:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[C:3](=[O:10])[NH:2]1.[CH3:11][CH:12]1[CH2:17][CH2:16][N:15]([C:18](Cl)=[O:19])[CH2:14][CH2:13]1>>[CH3:11][CH:12]1[CH2:17][CH2:16][N:15]([C:18]([O:10][C:3]2[C:4]3[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=3[S:1][N:2]=2)=[O:19])[CH2:14][CH2:13]1

Participants

3

Reactant 2

HCID 175201,2-Benzisothiazol-3(2H)-oneHCID 152215164-Methylpiperidine-1-carbonyl Chloride

Product 1

HCID 12001419HCID 12001419, compound

Procedure

In analogy to example 1, 45 mg (0.3 mmol) of benzo[d]isothiazol-3-one were reacted with 58 mg (0.36 mmol) of 4-methylpiperidine-1-carbonyl chloride. Yield: 26 mg (32%), M+H+: 277.14.

Sources & evidence

ORD record
ord-263ec48a56984562bca2a6ddd9017ccd
Source dataset
uspto-grants-2014_12
Patent number
US08921404B2

Reaction notes

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