4-(Trifluoromethyl)piperidine-1-carbonyl chloride → HCID 69153092, compound

HRID 1409993Notes

Reaction equation

HRID 1409993 reaction equation
[S:1]1[C:5]2=[N:6][CH:7]=[CH:8][CH:9]=[C:4]2[C:3]([OH:10])=[N:2]1.[F:11][C:12]([F:23])([F:22])[CH:13]1[CH2:18][CH2:17][N:16]([C:19](Cl)=[O:20])[CH2:15][CH2:14]1>>[F:22][C:12]([F:11])([F:23])[CH:13]1[CH2:18][CH2:17][N:16]([C:19]([O:10][C:3]2[C:4]3[C:5](=[N:6][CH:7]=[CH:8][CH:9]=3)[S:1][N:2]=2)=[O:20])[CH2:15][CH2:14]1

Participants

3

Reactant 2

HCID 798870814-(Trifluoromethyl)piperidine-1-carbonyl chlorideHCID 178519011HCID 178519011, compound

Product 1

HCID 69153092HCID 69153092, compound

Procedure

In analogy to example 1, 2.99 g (9.82 mmol) of isothiazolo[5,4-b]pyridin-3-ol were reacted with 2.33 g (10.81 mmol) of 4-trifluoromethylpiperidine-1-carbonyl chloride. Yield: 1.3 g (40%), M+H+: 332.09.

Sources & evidence

ORD record
ord-b3a33e200ae142de94aa4540bebe609c
Source dataset
uspto-grants-2014_12
Patent number
US08921404B2

Reaction notes

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