4-Methylpiperidine-1-carbonyl Chloride → HCID 86619685, compound

HRID 1409994Notes

Reaction equation

HRID 1409994 reaction equation
[Cl:1][C:2]1[N:7]=[C:6]2[O:8][N:9]=[C:10]([OH:11])[C:5]2=[CH:4][CH:3]=1.[CH3:12][CH:13]1[CH2:18][CH2:17][N:16]([C:19](Cl)=[O:20])[CH2:15][CH2:14]1>>[CH3:12][CH:13]1[CH2:18][CH2:17][N:16]([C:19]([O:11][C:10]2[C:5]3[C:6](=[N:7][C:2]([Cl:1])=[CH:3][CH:4]=3)[O:8][N:9]=2)=[O:20])[CH2:15][CH2:14]1

Participants

3

Reactant 2

HCID 152215164-Methylpiperidine-1-carbonyl ChlorideHCID 178518995HCID 178518995, compound

Product 1

HCID 86619685HCID 86619685, compound

Procedure

In analogy to example 1, 55 mg (0.32 mmol) of 6-chloroisoxazolo[5,4-b]pyridin-3-ol were reacted with 62.7 mg (0.39 mmol) of 4-methylpiperidine-1-carbonyl chloride. Yield: 22 mg (24%), M+H+: 296.04.

Sources & evidence

ORD record
ord-90216a9093a14e5e9655beb012cb3ff7
Source dataset
uspto-grants-2014_12
Patent number
US08921404B2

Reaction notes

Loading…