4-Methylpiperidine-1-carbonyl Chloride → HCID 69153636, compound

HRID 1409995Notes

Reaction equation

HRID 1409995 reaction equation
[CH3:1][C:2]1[N:7]=[C:6]2[O:8][N:9]=[C:10]([OH:11])[C:5]2=[CH:4][CH:3]=1.[CH3:12][CH:13]1[CH2:18][CH2:17][N:16]([C:19](Cl)=[O:20])[CH2:15][CH2:14]1>>[CH3:12][CH:13]1[CH2:18][CH2:17][N:16]([C:19]([O:11][C:10]2[C:5]3[C:6](=[N:7][C:2]([CH3:1])=[CH:3][CH:4]=3)[O:8][N:9]=2)=[O:20])[CH2:15][CH2:14]1

Participants

3

Reactant 2

HCID 152215164-Methylpiperidine-1-carbonyl ChlorideHCID 178422985HCID 178422985, compound

Product 1

HCID 69153636HCID 69153636, compound

Procedure

In analogy to example 1, 140 mg (0.93 mmol) of 6-methylisoxazolo[5,4-b]pyridin-3-ol were reacted with 181 mg (1.12 mmol) of 4-methylpiperidine-1-carbonyl chloride. Yield: 135 mg (53%), M+H+: 276.10.

Sources & evidence

ORD record
ord-124cae47f8e3400181fef78eb10c76e2
Source dataset
uspto-grants-2014_12
Patent number
US08921404B2

Reaction notes

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