Sodium Iodide → HCID 67120034, compound

Participants

Reaction Conditions

Reaction Steps

5-Bromo-1-(4-methoxyphenyl)-3-propyl-1H-pyrazole (287 mg, 0.97 mmol), 3,5-dimethylisoxazol-4-ylboronic acid (274 mg, 1.94 mmol), K2CO3 (806 mg, 5.83 mmol), sodium iodide (291 mg, 1.94 mmol) and Pd(PPh3)4 (90 mg, 0.08 mmol) were mixed with degassed dioxane (1 mL) and degassed H2O (1 mL) under nitrogen in a microwave vial. The reaction was heated at 150° C. for 20 min. The crude mixture was diluted with CH2Cl2 and washed with water. The organic phase was separated from the water phase, dried using a phase separator and evaporated. The crude product was purified on silica column (CH2Cl2:Et2O, 90:10) to give 4-(1-(4-methoxyphenyl)-3-propyl-1H-pyrazol-5-yl)-3,5-dimethylisoxazole (178 mg, 59%).

Provenance & Evidence