Boron tribromide → HCID 136350249, compound

Participants

Reaction Steps

methyl 4-(5-formyl-3-(4-methoxyphenyl)-1-methyl-1H-pyrazol-4-yl)-3,5-dimethylfuran-2-carboxylate (55 mg, 0.15 mmol) was dissolved in CH2Cl2 (7.5 mL) and BBr3 (1 M solution on DCM, 0.75 mL, 0.75 mmol) was added and stirred at room temperature over night. The reaction was quenched using water and extracted with CH2Cl2. Concentration and filtration trough a short plug of silica gave 4-(5-formyl-3-(4-hydroxyphenyl)-1-methyl-1H-pyrazol-4-yl)-3,5-dimethylfuran-2-carboxylic acid (45 mg, 75%) which was used as such in the next step.

Provenance & Evidence