Hydrochloric Acid → HCID 67113993, compound

Participants

Reaction Steps

A solution of 22.5 g 2-(benzhydrylideneamino)-3-(2-methoxyphenyl)propionitrile (66 mmol, crude product from 3.1) in 200 mL tetrahydrofuran was combined with 70 mL 1 M HCl and stirred for 3 hr at room temperature, and the reaction solution was then substantially concentrated on a rotary evaporator. After combination with methylene chloride the organic phase was extracted several times with 6 M HCl; the combined hydrochloric acid phases were made alkaline with 50% NaOH and extracted with methylene chloride, and the organic phase was then dried over Na2SO4 and concentrated. The oily residue (10.4 g) was used without further purification.

Provenance & Evidence